The White Sox jumped on Tribe starter Carlos Carrasco on Saturday night for five runs in the first in a 10-3 win.
The first four batters reached, and Carrasco lasted four innings after allowing a Carlos Sanchez homer in the fourth.
Jesus Aguilar, Giovanny Urshela and Ryan Raburn drove in runs for the Indians.
W: Chris Sale (9-6)
L: Carlos Carrasco (10-8)
HR: Carlos Sánchez (1, 4th inning off Carrasco 0 on, 2 Out).
Photo: Tony Dejak/AP Photo