The Indians rallied from an early 3-0 deficit to tie the Tigers, but Detroit countered with four in the fourth off Tribe starter Trevor Bauer for an 8-5 win.
Jason Kipnis had a two-run double and Michael Brantley followed with an RBI single to tie it in the third, but Miguel Cabrera drew an RBI, bases-loaded walk, Victor Martinez had a two-run single and Yoenis Cespedes followed with a sac fly.
David Murphy hit a pinch-hit homer in the eighth, his third pinch-hit homer this season. Roberto Perez added a homer of his own in the ninth.
W: Blaine Hardy (3-1)
L: Trevor Bauer (6-4)
HR: Yoenis Céspedes (10, 3rd inning off Bauer 0 on, 0 Out), David Murphy (4, 8th inning off Joba Chamberlain 0 on, 1 Out); Roberto Pérez (5, 9th inning off Soria 0 on, 2 Out).
Photo: Tony Dejak/AP Photo