The Indians and Blue Jays set a record by playing 16 innings on Opening Day before Toronto wins the game, 7 – 4, on a three-run homer by J.P. Arencibia off Jairo Asencio. The Indians take a 4 – 0 lead in the 2nd as Jack Hannahan hits a three-run homer off Ricky Romero, but do not score again over the next 14 frames. The Jays rally for 3 runs in the 9th off closer Chris Perez to negate a great start by Justin Masterson and send the game into extra innings.